Publications

2010
Geisbert T, Lee A, Robbins M, et al. Post exposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof of concept study. The Lancet, Vol 375, May 29, 2010. [Download PDF]

Semple SC, Akinc A, Chen J, et al. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol. Epub 2010 Jan 17. doi:10.1038/nbt.1602. Available at: http://www.nature.com/naturebiotechnology/ [PubMed] [Download PDF]

2009
Robbins M, Judge A, MacLachlan I. siRNA and innate immunity. Oligonucleotides. 2009 Jun;19(2):89-102. doi:10.1089/oli.2009.0180. [PubMed] [Download PDF]

Judge A, Robbins M, Tavikoli I, et al. Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice. J Clin Invest. 2009 Mar;119(3):438-42. doi: 10.1172/JCI37515.  [PubMed] [Download PDF]

2008
Robbins M, Judge A, Ambegia E, et al. Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation. Hum Gene Ther. 2008 Oct;19(10):991-9. doi:10.1089/hum.2008.131. [PubMed] [Download PDF]

Judge A, MacLachlan I. Overcoming the innate immune response to small interfering RNA. Hum Gene Ther. 2008 Feb;19(2):111-24. doi:10.1089/hum.2007.179. Epub 2008 Jan 29. [PubMed] [Download PDF]

MacLachlan I. Liposomal formulations for nucleic acid delivery. In: Crooke ST, editor. Antisense Drug Technology: Principles, Strategies, and Applications. Boca Raton (FL): CRC Press; 2008. p. 237-70. [Download PDF]

2007
Robbins M, Judge A, Liang L, McClintock K, Yaworski E, Maclachlan I. 2\' O-methyl-modified RNAs act as TLR7 antagonists. Mol Ther. 2007 Sep;15(9):1663-9. doi:10.1038/sj.mt.6300240. Epub 2007 Jun 19. [PubMed] [Download PDF]

Heyes J, Palmer L, Chan K, Giesbrecht C, Jeffs L, MacLachlan I. Lipid encapsulation enables the effective systemic delivery of polyplex plasmid DNA. Mol Ther. 2007 Apr;15(4):713-20. doi:10.1038/sj.mt.6300101. Epub 2007 Feb 13. [PubMed] [Download PDF]

2006
Geisbert TW, Hensley LE, Kagan E, et al. Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference. J Infect Dis. 2006 Jun 15;193(12):1650-7. doi: 10.1086/504267. Epub 2006 May 10. [PubMed] [Download PDF]

Heyes J, Hall K, Tailor V, Lenz R, MacLachlan I. Synthesis and characterization of novel poly(ethylene glycol)-lipid conjugates suitable for use in drug delivery. J Control Release. 2006 May 15;112(2):280-90. doi:10.1016/j.jconrel.2006.02.012. Epub 2006 Mar 6. [PubMed] [Download PDF]

Zimmermann TS, Lee AC, Akinc A, et al. RNAi-mediated gene silencing in non-human primates. Nature. 2006 May 4;441(7089):111-4. doi:10.1038/nature04688. Epub 2006 Mar 26. [PubMed] [Download PDF]

Judge A, Bola G, Lee ACH, MacLachlan I. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol Ther. 2006 Mar;13(3):494-505. doi:10.1016/j.ymthe.2005.11.002. Epub 2005 Dec 15. [PubMed] [Download PDF]

Judge A, McClintock K, Phelps JR, MacLachlan I. Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes. Mol Ther. 2006 Feb;13(2):328-37. doi:10.1016/j.ymthe.2005.09.014. Epub 2005 Nov 7. [PubMed] [Download PDF]

2005
Morrissey DV, Lockridge JA, Shaw L, et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat Biotechnol. 2005 Aug;23(8):1002-7. doi:10.1038/nbt1122. Epub 2005 Jul 24. [PubMed] [Download PDF]

Judge A, Sood V, Shaw J, Fang D, McClintock K, MacLachlan I. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol. 2005 Apr;23(4):457-62. doi:10.1038/nbt1081. Epub 2005 Mar 20. [PubMed] [Download PDF]

Heyes J, Palmer L, Bremner K, MacLachlan I. Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids. J Control Release. 2005 Oct 3;107(2):276-87. doi:10.1016/j.jconrel.2005.06.014. Epub 2005 Jul 28. [PubMed] [Download PDF]

Jeffs L, Palmer L, Ambegia E, Giesbrecht C, Ewanick S, MacLachlan I. A scalable, extrusion-free method for efficient liposomal encapsulation of plasmid DNA. Pharm Res. 2005 Mar;22(3):362-72. doi: 10.1007/s11095-004-1873-z. [PubMed] [Download PDF]

Ambegia E, Ansell S, Cullis P, Heyes J, Palmer L, MacLachlan I. Stabilized plasmid-lipid particles containing PEG-diacylglycerols exhibit extended circulation lifetimes and tumor selective gene expression. Biochim Biophys Acta. 2005 May 20;1669(2):155-63. doi:10.1016/j.bbamem.2005.02.001. Epub 2005 Mar 19. [PubMed] [Download PDF]

MacLachlan I, Cullis PR. Diffusible-PEG-lipid stabilized plasmid lipid particles. In: Huang L, Hung M-C, Wagner E, editors. Non-viral Vectors. New York (NY): Elsevier; 2005. p. 157-188. [Download PDF]

Finn J, MacLachlan I, Cullis P. Factors limiting autogene-based cytoplasmic expression systems. FASEB J. 2005 Apr;19(6):608-10. doi: 10.1096/fj.04-2769fje. Epub 2005 Jan 26. [PubMed] [Download PDF]